Program

The program of the International RAB symposium on regulatory autoantibodies targeting G-protein-coupled receptors will address the field of GPCR antibody research with specific highlights on:

anti-GPCR antibodies as biomarker in disease and therapeutic response
anti-GPCR antibody-mediated pathways
regulation of anti-GPCR abs
Identification of novel therapeutic targets

Why to join?

Our aim is to bring scientists together, initiate discussions and stimulate research on these challenges. We would like to strengthen the research network to:

identify new pathogenic targets, biomarkers and signalling pathways to find a holistic way to understand diseases
To identify effectors that influence the disease-specific transcriptome and secretome
understand how environmental factors and genes can be transformed into molecular pathways
Develop novel therapeutic strategies

Programm Download (PDF)

09:00 - 09:10

09:00 - 09:10
Opening
Gabriela Riemekasten, Yehuda Shoenfeld, Carmen Scheibenbogen

09:10 - 10:00

09:10 - 10:00
Provocative statements
Chairs: Carmen Scheibenbogen, Harald Heidecke

09:10

09:10

All diseases are autoimmune diseases

Yehuda Shoenfeld | Tel Aviv University Zabludowicz Center for Autoimmune Diseases, Tel Aviv, Israel

09:35

09:35

All diseases are GPCR abs mediated diseases

Gabriela Riemekasten | UKSH, Campus Lübeck, Lübeck, Germany

10:00 - 10:30

10:00 - 10:30
Coffee Break

10:30 - 12:15

10:30 - 12:15
COVID-19 and natural regulatory abs
Chairs: Gabriela Riemekasten, Hanna Graßhoff

10:30

10:30

Anti-GPCR abs in acute COVID-19 infection

Otavio Cabral Marques | University of São Paulo, São Paulo, Brazil

11:00

11:00

COVID-Vaccination and anti-GPCR abs

Tanja Lange | UKSH, Campus Lübeck, Lübeck, Germany

11:30

11:30

Role of GPCR abs in Post-COVID syndrome

Carmen Scheibenbogen | Charité Universitätsmedizin, Berlin, Germany

12:00

12:00

PAR-1 abs in acute COVID-19 infection

Reza Akbarzadeh | Universität Lübeck, Rheumatologie

12:15 - 13:00

12:15 - 13:00
Lunch Break

13:00 - 14:15

13:00 - 14:15
Poster Talks, followed by discussion in the poster exhibition
Chairs: Alexander Hackel, Antje Müller

13:07

13:07

Autoantibodies from Systemic Sclerosis patients targeting the angiotensin II type 1 and endothelin-1 type A receptor induce endothelial cell activation and pro-fibrotic responses

Wieke van Oostveen, Bryan Koolmoes, Nivine Levarht, Rudmer Postma, Vincent van Duinen, Anton Jan van Zonneveld, Gabriela Riemekasten, Rene Toes, Jeska de Vries-Bouwstra, Cynthia Fehres

13:14

13:14

Functional autoantibodies against the angiotensin II type I receptor (AT1R) in systemic sclerosis (SSc): influence of autologous stem cell transplantation (aSCT) and correlation with clinical outcome

Beate Preuß, Lukas Bankamp, Ann-Christin Pecher, Joerg Henes, Reinhild Klein

13:21

13:21

Different parts of ETAR N-terminus are involved in the receptor activation depending of the ligand

Michael Adu Gyamfi, Rusan Catar, Christian Lücht, Gunnar Kleinau, Michal Szczepek, Klemens Budde, Patrick Scheerer, Aurélie Philippe

13:28

13:28

GPCRs at the blood-brain barrier – focus on the role of G?q/11 signaling

Jan Wenzel, Dorothea Ziemens, Dimitrios Spyropoulos, Markus Schwaninger

13:35

13:35

Personalized immune analyses: epitope mapping of the immunome

Michael Szardenings, Nicolas Delaroque, Markus Fischer, Karolin Kern, Marcus Puder, Lisbeth Ramirez Caballero, Dorothee Wehrmann, Eva Ehrentreich-Förster

14:15 - 15:45

14:15 - 15:45
Progress in preclinical models to measure RAB ab effects
Chairs: Lars Klareskoog, Thomas P. Sakmar

14:15

14:15

Animal models

Xinhua Yu | Research Center Borstel, Borstel, Germany

14:45

14:45

Modification of animal models and GPCR/monoclonal abs

Frank Petersen | Research Center Borstel, Borstel, Germany

15:15

15:15

Stroke and anti-GPCR abs

Matthias Endres | Charité Universitätsmedizin, Berlin, Germany

15:45 - 16:15

15:45 - 16:15
Coffee Break

16:15 - 17:20

16:15 - 17:20
Anti-GPCR binding biology
Chairs: Frank Petersen, Xinhua Yu

16:15

16:15

Multiplexed validation of anti-GPCR antibodies

Thomas P. Sakmar | Rockefeller University, New York, United States

16:45

16:45

Glycokalyx as novel player for anti-GPCR abs and for the modulation of receptor stimulation?

Mai Jäpel | UKSH, Campus Lübeck, Lübeck, Germany

17:05

17:05

Antibody-induced proteom

Paulina Mackedanz | UKSH, Campus Lübeck, Lübeck, Germany

17:20 - 17:25

17:20 - 17:25
Closing Day 1
Gabriela Riemekasten

17:25 - 18:30

17:25 - 18:30
Get-together in exhibition

06:30 - 07:30

06:30 - 07:30
The natural and green zone of Lübeck- a jogging experience in the morning
Gabriela Riemekasten

09:00 - 10:25

09:00 - 10:25
Natural RAB-induced signalling
Chairs: Jürgen Bernhagen, Carmen Scheibenbogen

09:00

09:00

Antibody cluster in vasculitis patients

Carlotta Meyer

09:15

09:15

Signalling of GPCR abs in different cellular models

Rusan A. Catar | Charité Universitätsmedizin, Berlin, Germany

09:55

09:55

Anti-GPCR-abs as Biomarker for PsA and Colitis Ulcerosa

Hanna Graßhoff | UKSH, Campus Lübeck, Lübeck, Germany

10:25 - 10:55

10:25 - 10:55
Coffee Break

10:55 - 11:55

10:55 - 11:55
Therapy
Chairs: Camilla Svensson, Tanja Lange

10:55

10:55

Aptamer BQ007, a novel therapeutic agent?

Bettina Hohberger | Universitätsklinikum Erlangen, Erlangen, Germany

11:25

11:25

Interfering with atherogenic GPCR functions by peptides

Jürgen Bernhagen | Institute for Stroke and Dementia Research (ISD) University Hospital Munich, München, Germany

11:55 - 13:00

11:55 - 13:00
Lunch in the industrial exhibition

13:00 - 14:35

13:00 - 14:35
Fibromyalgia and ME/CSF as another challenge
Chairs: Otavio Cabral-Marques, Carmen Scheibenbogen

13:00

13:00

Fibromyalgia: ab-mediated pathogenesis

Camilla I. Svensson | Karolinska Institutet, Stockholm, Sweden

13:30

13:30

Role of GPCR abs in chronic fatigue syndrome

Franziska Sotzny | Charité Universitätsmedizin, Berlin, Germany

14:00

14:00

Functional (catalytic) antibodies unravel autoimmune frequency in psychiatric disorders

Kamalanathan AS Sivasankaran | Centre for BioSeparation Technology, Vellore Institute of Technology (VIT), Vellore, Tamil Nadu, India

14:20

14:20

GPCR abs and confounding factors: Learning from fibromyalgia

Tanja Lange | UKSH, Campus Lübeck, Lübeck, Germany

14:35 - 15:05

14:35 - 15:05
Coffee Break

15:05 - 16:30

15:05 - 16:30
New pathogenesis insights from SSc
Chairs: Reza Akbarzadeh, Yehuda Shoenfeld

15:05

15:05

GPCR abs in systemic sclerosis

Susanne Schinke | UKSH, Campus Lübeck, Lübeck, Germany

15:30

15:30

CXCR3 abs and cardiovascular diseases

Felix Müller | Universitätsmedizin Mainz, Mainz, Germany

15:50

15:50

Metabolom and anti-GPCR abs

Sebastian Jendrek | UKSH, Campus Lübeck, Lübeck, Germany

16:10

16:10

GPCR abs and EVs in SSc - the bad boys affecting immune cell function

Alexander M. Hackel | UKSH, Campus Lübeck, Lübeck, Germany

16:30 - 16:40

16:30 - 16:40
Break

16:40 - 17:10

16:40 - 17:10
Lecture
Chair: Gabriela Riemekasten

16:40

16:40

EVs and antibody-interactions

David S. Pisetsky | Duke University School of Medivine, Durham, United States

17:10 - 17:30

17:10 - 17:30
Closing
Gabriela Riemekasten, Yehuda Shoenfeld, Carmen Scheibenbogen

17:10

17:10

What are the next steps, how to proceed? - General discussion

17:25

17:25

Closing remarks

Gabriela Riemekasten | UKSH, Campus Lübeck, Lübeck, Germany